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In enzymology, a dihydropyrimidine dehydrogenase (NADP+) () is an enzyme that catalyzes the chemical reaction :5,6-dihydrouracil + NADP+ uracil + NADPH + H+ Thus, the two substrates of this enzyme are 5,6-dihydrouracil and NADP+, whereas its 3 products are uracil, NADPH, and H+. This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 5,6-dihydrouracil:NADP+ 5-oxidoreductase. Other names in common use include: * dihydrothymine dehydrogenase *dihydrouracil dehydrogenase (NADP+) *4,5-dihydrothymine: oxidoreductase *DPD *DHPDH *dehydrogenase, dihydrouracil (nicotinamide adenine dinucleotide, phosphate) *DHU dehydrogenase *hydropyrimidine dehydrogenase *dihydropyrimidine dehydrogenase (NADP+) This enzyme participates in 3 metabolic pathways: pyrimidine metabolism, beta-alanine metabolism, and pantothenate and coa biosynthesis. ==Structural studies== As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes , , , , and . 抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「Dihydropyrimidine dehydrogenase (NADP+)」の詳細全文を読む スポンサード リンク
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